In vitro Dissolution Studies of Different Brands of Baclofen Tablets Available in Bangladesh

Abstract

This study was designed to evaluate the quality of baclofen tablets commercially available in Bangladesh. We studied the in vitro dissolution profile of eleven brands of baclofen tablet of which three were coated and eight uncoated. The study also included the determination of disintegration time and drug content in all these brands. We observed that one of the film-coated brands was suboptimal with respect to average drug content, which was found to be 80.10% and this lies outside the compendial specification. This brand also failed to comply with the compendial in vitro drug release requirement as we observed only 41.30% drug release at the end of 45 min. All other brands tested met the required specifications and complied accordingly in terms of drug release, disintegration time and drug content. In conclusion, our results demonstrate that although most brands of baclofen tablets included in this study showed high dissolution profile and hence good bioavailability, at least one brand failed to meet the quality requirements, suggesting that substandard product is also available in the market that may not provide the expected efficacy.