Potential Enhancers for Transdermal Drug Delivery: A Review

Abstract

Transdermal drug delivery system (TDDS) aims to deliver the therapeutic moiety via the skin into the systemic circulation for its therapeutic effect. The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal in case of side effects, and better patient compliance. However, due to resistance of this route is the difficulty of penetration of drug through the skin. Studies have been carried out to select safe and suitable penetration enhancers to promote the percutaneous absorption of a number of drugs. The present review contains the different penetration enhancers; thus, it will help in the selection of appropriate enhancers for increasing the permeation of poorly absorbed drugs through skin