Antibacterial and Phytochemical Evaluation of the crude extract and Fractions of Eremostachys laciniata.

Hameed Ur Rehman,Rumana Saeed,Tahir, Nisar Ahmad, M. Gul Riaz Khan,Tallat M, Munir, Hameed Shabab Alam, Maimoona Saddique, Ikram Ullah Shah, M. M. Aslam, Zainab Gul


The aim of the present research was to evaluate the antimicrobial potential and phytochemical profile of
Eremostachys laciniata plant to look into possible natural therapy agents. The shade-dried whole plant material of
Eremostachys laciniata was soaked in methanol for 10 days. The powdered drug was extracted with 80 % methanol three
times and filtered at room temperature. The filtrate was evaporated in rotary to get a dark-greenish residue (extract), which was
further suspended in water and partitioned successively with n-hexane, chloroform, distill water and n-butanol to obtain nhexane-
soluble, chloroform-soluble, distill water-soluble, n-butanol soluble and aqueous fractions, respectively. Different
fractions (chloroform, n-hexane, butanol, water and ethyl acetate) of the plant were tested against various bacterial strains
namely E.coli, S.aureus, S.typheae, P.auriginosa.The extracted fractions of the plant exhibit moderate activities showing 9mm
to 18mm inhibition against different strains of bacteria as compared to the control, which gave maximum inhibition upto
29mm. The Eremostachys laciniata was found to be good source of alkaloids, flavonoids, tennins, resins, carbohydrate, starch,
proteins, glycosides, coumarin, terponides, steroids and saponine. Anthranol glycosides were absent in the plant. The above
results revealed that Fagonia cretica have an excellent anti-bacterial activity and can be used for disease therapy.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963